The clinical and public health value of non-culture methods in the investigation of a cluster of unexplained pneumonia cases
Identifieur interne : 003876 ( Main/Exploration ); précédent : 003875; suivant : 003877The clinical and public health value of non-culture methods in the investigation of a cluster of unexplained pneumonia cases
Auteurs : C. L. Sheppard [Royaume-Uni] ; J. E. Salmon [Royaume-Uni] ; T. G. Harrison [Royaume-Uni] ; M. Lyons [Royaume-Uni] ; R. C. George [Royaume-Uni]Source :
- Epidemiology and Infection [ 0950-2688 ] ; 2008.
Abstract
During 2003, a cluster of initially unexplained pneumonia cases (two fatal) occurred in patients aged <50 years in a British city. Routine culture tests were inconclusive, however, pneumococcal infection was suspected and the putative outbreak was investigated using non-culture methods. Clinical samples from ten patients were tested by pneumococcal polymerase chain reaction (PCR) and multi-locus sequence typing (MLST), or Binax NOW® pneumococcal urine antigen test and serotype-specific enzyme-linked immunosorbent assay (ELISA). Lung samples from the deceased patients were PCR positive and yielded different MLST types. Two patients in one family group were serotype 1 pneumococcal antigen positive. Two further patients were serotype 1 antigen positive, and one serotype 4 positive. Two antigen-positive cases were also serum PCR positive. Non-culture methods confirmed the disease aetiology in six cases. Serotype and MLST results showed no single outbreak, but a family cluster of cases in a high background of pneumococcal pneumonia, providing important epidemiological data that would not otherwise have been available.
Url:
DOI: 10.1017/S0950268807009302
Affiliations:
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Clinical samples from ten patients were tested by pneumococcal polymerase chain reaction (PCR) and multi-locus sequence typing (MLST), or Binax NOW® pneumococcal urine antigen test and serotype-specific enzyme-linked immunosorbent assay (ELISA). Lung samples from the deceased patients were PCR positive and yielded different MLST types. Two patients in one family group were serotype 1 pneumococcal antigen positive. Two further patients were serotype 1 antigen positive, and one serotype 4 positive. Two antigen-positive cases were also serum PCR positive. Non-culture methods confirmed the disease aetiology in six cases. Serotype and MLST results showed no single outbreak, but a family cluster of cases in a high background of pneumococcal pneumonia, providing important epidemiological data that would not otherwise have been available.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sheppard, C L" sort="Sheppard, C L" uniqKey="Sheppard C" first="C. L." last="Sheppard">C. L. Sheppard</name></region><name sortKey="George, R C" sort="George, R C" uniqKey="George R" first="R. C." last="George">R. C. George</name><name sortKey="Harrison, T G" sort="Harrison, T G" uniqKey="Harrison T" first="T. G." last="Harrison">T. G. Harrison</name><name sortKey="Lyons, M" sort="Lyons, M" uniqKey="Lyons M" first="M." last="Lyons">M. Lyons</name><name sortKey="Salmon, J E" sort="Salmon, J E" uniqKey="Salmon J" first="J. E." last="Salmon">J. E. Salmon</name><name sortKey="Sheppard, C L" sort="Sheppard, C L" uniqKey="Sheppard C" first="C. L." last="Sheppard">C. L. Sheppard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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